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Pituitary organoids can be formed from human or mouse embryonic stem cells, or from human induced pluripotent stem cells Here, we established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem cell biology. Human pituitary organoid transplantation is sufficient to induce corticosterone release in hypophysectomized mice, raising the possibility of therapeutic applications.
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The pituitary is the core endocrine gland, ruling fundamental processes of body growth, metabolism, reproduction and stress The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and role remain poorly characterized Over the past decade, it has progressively become clear that the pituitary, like many adult tissues, harbors a population of stem cells
While the molecular depiction of these cells is constantly expanding, their function remains essentially hidden
Stem cells have been shown to play a role in recurrent malignancies in some tissues, and their role in pituitary hyperplasia, pituitary adenomas, and tumors is an important area for future investigation. Pituitary stem cell biology has emerged as a pivotal field in understanding the maintenance and regeneration of the neuroendocrine system Research in this domain has illuminated the role of. Not only their physiological role is still largely unknown, also whether or how these stem cells are involved in pituitary disease and recovery from defective functionality remains enigmatic.
